PDRN

PDRN Explained: Advanced Support For Skin Repair

PDRN, short for polydeoxyribonucleotide, is a regenerative skincare ingredient recognised for its ability to support skin recovery and barrier resilience. Often associated with advanced aesthetic treatments, PDRN is now formulated into serums and creams designed to calm, hydrate and visibly improve compromised or ageing skin.

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SkinCeuticals Phyto Corrective PDRN SerumSkinCeuticals Phyto Corrective PDRN Serum
SkinCeuticals Phyto Corrective PDRN Serum

From €84,50
Medicube PDRN Pink Peptide Serum 30mlMedicube PDRN Pink Peptide Serum 30ml
Medicube PDRN Pink Peptide Serum 30ml

€13,95
Box of Medicube pink collagen gel masks on a white backgroundMedicube PDRN Pink Collagen Gel Mask (4EA)
Medicube PDRN Pink Collagen Gel Mask (4EA)

€11,95
Medicube PDRN Pink Peptide Eye Cream 30mlMedicube PDRN Pink Peptide Eye Cream 30ml
Medicube PDRN Pink Peptide Eye Cream 30ml

€13,95
Pink collagen capsule cream jar with 'medicube' branding on a white backgroundMedicube PDRN Pink Collagen Capsule Cream 55g
Medicube PDRN Pink Collagen Capsule Cream 55g

€19,95
Medicube serum mist bottle on a white backgroundMedicube PDRN Pink Glutathione Serum Mist 100ml
Medicube PDRN Pink Glutathione Serum Mist 100ml

€14,95
Pink tube of Medicube hair product on a white backgroundMedicube PDRN Booster Gel 300ml
Medicube PDRN Booster Gel 300ml

€13,95
Medicube PDRN Pink Hyaluronic Moisturizing Cream 50mlMedicube PDRN Pink Hyaluronic Moisturizing Cream 50ml
Medicube PDRN Pink Hyaluronic Moisturizing Cream 50ml

€13,95
Medicube pink toner bottle on a white backgroundMedicube PDRN Pink Cica Soothing Toner 250ml
Medicube PDRN Pink Cica Soothing Toner 250ml

€13,95
New
Tube of Expert Madeca Cream on a white backgroundCentellian24 Expert Madeca Cream Active Renew PDRN 50ml
Centellian24 Expert Madeca Cream Active Renew PDRN 50ml

€20,95
COSRX PDRN EXOSOME Skinplaning Glaze Mask 50mlCOSRX PDRN EXOSOME Skinplaning Glaze Mask 50ml
COSRX PDRN EXOSOME Skinplaning Glaze Mask 50ml

€14,95
Medicube PDRN Pink Vita Coating Mask (Single)Medicube PDRN Pink Vita Coating Mask (Single)
Medicube PDRN Pink Vita Coating Mask (Single)

€2,95
Pink skincare serum bottle with 'medicube' branding on a white backgroundMedicube PDRN Pink Collagen Exosome Shot 2000 Ampoule 30ml
Medicube PDRN Pink Collagen Exosome Shot 2000 Ampoule 30ml

€15,95
Medicube PDRN Pink One Day Serum Set 10 x 1.5mlMedicube PDRN Pink One Day Serum Set 10 x 1.5ml
Medicube PDRN Pink One Day Serum Set 10 x 1.5ml

€11,95
Pink collagen gel mask with packaging on a white backgroundMedicube PDRN Pink Collagen Gel Mask (Single)
Medicube PDRN Pink Collagen Gel Mask (Single)

€3,95
haruharu wonder Rose PDRN Firming Serum 30mlharuharu wonder Rose PDRN Firming Serum 30ml
haruharu wonder Rose PDRN Firming Serum 30ml

€12,95

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Pink packaging of Medicube PDRN Pink Collagen Toning Gel Toner Pad on a white backgroundMedicube PDRN Pink Collagen Gel Toner Pads x70
Medicube PDRN Pink Collagen Gel Toner Pads x70

€17,95
Eqqualberry Pore Fit Purple PDRN Pore Minimising Serum 30mlEqqualberry Pore Fit Purple PDRN Pore Minimising Serum 30ml
Eqqualberry Pore Fit Purple PDRN Pore Minimising Serum 30ml

€14,95
New
Pai Skincare PDRN Revival Moisturiser 50mlPai Skincare PDRN Revival Moisturiser 50ml
Pai Skincare PDRN Revival Moisturiser 50ml

€66,95
New
Centellian24 360Β° Shot PDRN Glowing Eye Patch 1 PairCentellian24 360Β° Shot PDRN Glowing Eye Patch 1 Pair
Centellian24 360Β° Shot PDRN Glowing Eye Patch 1 Pair

€2,95
Eqqualberry Green Aid Aloe PDRN Calming Toner 150mlEqqualberry Green Aid Aloe PDRN Calming Toner 150ml
Eqqualberry Green Aid Aloe PDRN Calming Toner 150ml

€9,95
haruharu wonder Rose PDRN Soothing Serum 30mlharuharu wonder Rose PDRN Soothing Serum 30ml
haruharu wonder Rose PDRN Soothing Serum 30ml

€14,95
Eqqualberry Green Aid Aloe PDRN Calming Serum 30mlEqqualberry Green Aid Aloe PDRN Calming Serum 30ml
Eqqualberry Green Aid Aloe PDRN Calming Serum 30ml

€16,95
Sold out
Dr. Althea PDRN Reju 5000 Cream 20gDr. Althea PDRN Reju 5000 Cream 20g
Dr. Althea PDRN Reju 5000 Cream 20g

€23,95
Sold out
Rodial Salmon DNA Water-Oil 30mlRodial Salmon DNA Water-Oil 30ml
Rodial Salmon DNA Water-Oil 30ml

€155,95
Sold out
Pink skincare product bottle with 'medicube' branding on a white backgroundMedicube PDRN Pink Collagen Exosome Shot 7500 Ampoule 30ml
Medicube PDRN Pink Collagen Exosome Shot 7500 Ampoule 30ml

€15,95
Sold out
Rodial Salmon DNA Water-Oil 18mlRodial Salmon DNA Water-Oil 18ml
Rodial Salmon DNA Water-Oil 18ml

€93,95
Sold out
Rodial Salmon DNA Jelly Eye Patches x4 PackRodial Salmon DNA Jelly Eye Patches x4 Pack
Rodial Salmon DNA Jelly Eye Patches x4 Pack

€58,95
Sold out
Skincare tube labeled '360 Shot' on a white backgroundCentellian24 360Β° Shot PDRN Lifting Eye Cream 30ml
Centellian24 360Β° Shot PDRN Lifting Eye Cream 30ml

€14,95
Sold out
Biodance rejuvenating caviar PDRN real deep mask packaging on a white backgroundBiodance Rejuvenating Caviar PDRN Real Deep Mask 34g
Biodance Rejuvenating Caviar PDRN Real Deep Mask 34g

€5,95
Sold out
Rodial Salmon DNA Hydrogel Face Mask x4 PackRodial Salmon DNA Hydrogel Face Mask x4 Pack
Rodial Salmon DNA Hydrogel Face Mask x4 Pack

€77,95
Sold out
Rodial Salmon DNA Hydrogel Face MaskRodial Salmon DNA Hydrogel Face Mask
Rodial Salmon DNA Hydrogel Face Mask

€20,95
Sold out
Rodial Salmon DNA Jelly Eye PatchesRodial Salmon DNA Jelly Eye Patches
Rodial Salmon DNA Jelly Eye Patches

€15,95
PDRN

About PDRN

Discover The Science Behind PDRN

PDRN, or polydeoxyribonucleotide, is a DNA-derived ingredient recognised for its regenerative properties in skincare. Commonly sourced from salmon, it is valued for supporting skin repair, improving resilience and encouraging a smoother, more refined appearance.

Find Your Perfect Barrier Supporting Formula

From lightweight PDRN serums to nourishing creams, these advanced formulations help calm stressed skin, reinforce the barrier and promote visible renewal. Ideal for compromised, sensitive or ageing skin, PDRN works alongside hydrating and strengthening ingredients for balanced results.

Personalised Advice On PDRN Skincare

If you’re unsure whether PDRN is right for your skin, you can take our free online skin test, read our blog for expert guidance, or contact us for personalised support from our skincare specialists.

Expert Tip for Using PDRN

"Apply your PDRN serum to clean, slightly damp skin before moisturiser to maximise absorption and support barrier recovery. This allows the regenerative ingredients to work efficiently while sealing in hydration with a nourishing cream. Consistent use is key when targeting compromised or ageing skin. A balanced routine will help maintain strength, comfort and visible improvement over time."

– Kimberley, Clinic & Customer Experience Manager

take the free skin test

Support Stronger, Healthier Looking Skin With PDRN

Expertly formulated PDRN serums and creams designed to promote skin repair, reinforce the barrier and improve overall texture. Ideal for stressed, sensitised or post-treatment skin, these advanced formulas combine innovation with gentle, restorative care.
Medicube PDRN Pink Hyaluronic Moisturizing Cream 50mlMedicube PDRN Pink Hyaluronic Moisturizing Cream 50ml
Medicube PDRN Pink Hyaluronic Moisturizing Cream 50ml

€13,95
Medicube serum mist bottle on a white backgroundMedicube PDRN Pink Glutathione Serum Mist 100ml
Medicube PDRN Pink Glutathione Serum Mist 100ml

€14,95
Box of Medicube pink collagen gel masks on a white backgroundMedicube PDRN Pink Collagen Gel Mask (4EA)
Medicube PDRN Pink Collagen Gel Mask (4EA)

€11,95
Medicube pink toner bottle on a white backgroundMedicube PDRN Pink Cica Soothing Toner 250ml
Medicube PDRN Pink Cica Soothing Toner 250ml

€13,95
Pink tube of Medicube hair product on a white backgroundMedicube PDRN Booster Gel 300ml
Medicube PDRN Booster Gel 300ml

€13,95
Medicube PDRN Pink Peptide Serum 30mlMedicube PDRN Pink Peptide Serum 30ml
Medicube PDRN Pink Peptide Serum 30ml

€13,95

Frequently Asked Questions

What does PDRN stand for?

PDRN stands for polydeoxyribonucleotide. It is a DNA-derived ingredient, commonly sourced from salmon, used in skincare for its regenerative and skin-repairing properties.

What does PDRN do for the skin?

PDRN helps support skin recovery, improve barrier resilience and promote a smoother, more even-looking complexion. It is often used to calm stressed or compromised skin.

Is PDRN good for damaged skin barrier?

Yes, PDRN is frequently included in barrier repair skincare as it helps reinforce skin resilience and support recovery after environmental stress or aesthetic treatments.

Can PDRN help with anti-ageing concerns?

PDRN is associated with skin renewal and improved elasticity, making it beneficial for targeting fine lines, dullness and loss of firmness.

Is PDRN suitable for sensitive skin?

Many PDRN formulations are designed to be gentle and calming, making them suitable for sensitive or redness-prone skin types. Always patch test first.

Can PDRN be used with retinol or acids?

PDRN can often be paired with active ingredients like retinol or exfoliating acids to support recovery and minimise irritation. Introduce gradually and follow professional guidance.

Is PDRN the same as hyaluronic acid?

No, hyaluronic acid primarily focuses on hydration, while PDRN is positioned as a regenerative ingredient that supports repair and skin renewal. They can complement each other in a routine.